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Product Name
Anti-MAGEA3 Rabbit antibody
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Description
MAGEA3 Rabbit polyclonal antibody
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Tested applications
WB
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Species reactivity
Human
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Alternative names
HIP8; HYPD; CT1.3; MAGE3; MAGEA6 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant protein of human MAGEA3
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Clonality
Polyclonal
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Formulation
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage instructions
Store at -20°C. Stable for 12 months from date of receipt.
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Applications
WB: 1/1000
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Validations
Western blot detection of MAGEA3 in Hela cell lysates using MAGEA3 Rabbit pAb(1:1000 diluted).Predicted band size:35kDa.Observed band size:45kDa.
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Background
Swiss-Prot Acc.P43357.Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"