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Product Name
Anti-IL-3 antibody
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Description
Rabbit polyclonal to IL-3
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Tested applications
IHC-P
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Species reactivity
Mouse IL3
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Alternative names
BPA antibody; PSF antibody; HCGF antibody; Il-3 antibody; MCGF antibody; Csfmu antibody; IL-3 antibody; MCGF antibody; MULTI-CSF antibody; Csfmu antibody; IL3 antibody; IL-3 antibody; MCGF antibody; MCGF antibody; MGC79398 antibody; PSF antibody; RP23-309E16.5 antibody; BPA antibody; HCGF antibody; Il3 antibody; IL-3 antibody; MGC79399 antibody; MULTI-CSF antibody
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Isotype
Rabbit IgG
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Preparation
Produced in rabbits immunized with A synthetic peptide corresponding to the N-terminus of the mouse IL3., and purified by antigen affinity chromatography.
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Clonality
Polyclonal
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Formulation
0.2 μm filtered solution in PBS
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Storage instructions
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles. -
Applications
IHC-P: 0.1-2 μg/mL
IP: 1-4 μg/mg of lysate
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Validations
IL3 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
IL3 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of mouse IL3 in mouse kidney with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
IL3 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Immunochemical staining of mouse IL3 in mouse uterus with rabbit polyclonal antibody (0.2 µg/mL, formalin-fixed paraffin embedded sections).
IL3 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Background
IL3 (interleukin 3), also known as IL-3, is a potent growth promoting cytokine which belongs to the IL-3 family. IL3/IL-3 also belongs to the group of interleukins. Interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells. IL3/IL-3 is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. IL3/IL-3 has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders.
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References
- Meyer CG, et al.. (2011) IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. Hum Mol Genet. 20(6):1173-81.
- Zambrano A, et al. (2010) IL-3 controls tau modifications and protects cortical neurons from neurodegeneration. Curr Alzheimer Res. 7(7):615-24.
- Dentelli P, et al.. (2011) IL-3 is a novel target to interfere with tumor vasculature. Oncogene. 30(50):4930-40.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"