Anti-IDO2 antibody

Anti-IDO2 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit polyclonal to IDO2

ELISA, WB

Human IDO2

3 dioxygenase-like 1 antibody; 3 dioxygenase-like 1 antibody; 3-dioxygenase-like 1 protein antibody; 3-dioxygenase-like protein 1 antibody; 3-dioxygenase-like protein 1 antibody; AI265623 antibody; C230043N17 antibody; C230043N17Rik antibody; Ido-2 antibody; IDO-2 antibody; INDOL1 antibody; Indol1 antibody; indoleamine 2 antibody; indoleamine 2 antibody; indoleamine-pyrrole 2 antibody; indoleamine-pyrrole 2 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Human IDO2 (rh IDO2; Q6ZQW0-1; Met1-Gly407). IDO2 specific IgG was purified by Human IDO2 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human tissues, its physiological role is not fully understood but is of great interest. IDO can be up-regulated via cytokines such as interferon-gamma, and can thereby modulate the levels of tryptophan, which is vital for cell growth. In humans and mice, the IDO1 and IDO2 genes are present tandemly in a tail-to-head arrangment on chromosome 8. In lower vertebrates such as zebrafish and toads only a single IDO gene may be present that may be more IDO2-like in structure. This closer relationship to IDO2 suggests that IDO2 may actually be the ancestor of the better characterized IDO1 gene, and that IDO1 might have been generated by gene duplication of IDO2 before the origin of tetrapods in mammalian evolutionary history. IDO2 catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism.

• Witkiewicz AK, et al. (2009) Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 208 (5): 781-7.
• Sorensen RB, et al. (2011) Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. Cancer Res. 71 (6): 2038-44.
• Witkiewicz AK, et al. (2009) Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. J Am Coll Surg. 208 (5): 781-7.