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Product Name
Anti-gamma Catenin (4B4) Mouse antibody
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Description
gamma Catenin (4B4) Mouse monoclonal antibody
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Tested applications
WB, IHC-P, ICC/IF, IP
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Species reactivity
Human
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Isotype
Mouse IgG1
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Preparation
Antigen: Purified recombinant fragment of human JUP expressed in E. Coli.
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Clonality
Monoclonal
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Formulation
Ascitic fluid containing 0.03% sodium azide.
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
ICC: 1/200 - 1/1000
ELISA: 1/10000
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Validations
Immunohistochemical analysis of paraffin-embedded rectum tissues using JUP mouse mAb with DAB staining.
Western blot detection of γ-Catenin in A549,Hela and 3T3 cell lysates using γ-Catenin mouse mAb (1:1000 diluted).Predicted band size:82KDa.Observed band size:82KDa.
Immunoprecipitation analysis of Hela cell lysates using γ-Catenin mouse mAb.
Immunofluorescence analysis of U251 cells using JUP mouse mAb (green). Blue
Immunohistochemical analysis of paraffin-embedded stomach cancer tissues using JUP mouse mAb with DAB staining.
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Background
Swiss-Prot Acc.P14923.This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described.
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