Anti-DDR1 antibody

Anti-DDR1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit Polyclonal to Rat DDR1

WB, IHC-P

Rat DDR1/MCK10/CD167

NEP antibody; NEP antibody; 6030432F18 antibody; AI323681 antibody; Cak antibody; CAK antibody; CD167 antibody; CD167a antibody; DAAP-278B20.1 antibody; DDR antibody; Ddr1 antibody; NEP antibody; NEP antibody; DDR1 antibody; EDDR1 antibody; MCK10 antibody; NTRK4 antibody; PTK3 antibody; PTK3A antibody; PTK3A antibody; RTK6 antibody; TRKE antibody; CAK antibody; DDR antibody; HGK2 antibody; PTK3 antibody; RTK6 antibody; TRKE antibody; CD167 antibody; EDDR1 antibody; MCK10 antibody; NTRK4 antibody; PTK3A antibody; Cak antibody; PTK3A antibody; CD167a antibody; AI323681 antibody; 6030432F18 antibody

Rabbit IgG

Produced in rabbits immunized with purified, recombinant Rat DDR1/MCK10/CD167 . DDR1/MCK10/CD167 specific IgG was purified by Rat DDR1/MCK10/CD167 affinity chromatography.

Polyclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Discoidin domain receptor family, member 1 (DDR1), also known as or CD167a (cluster of differentiation 167a), and Mammary carcinoma kinase 10 (MCK10), belongs to a subfamily of tyrosine kinase receptors with an extracellular domain homologous to Dictyostellium discoideum protein discoidin 1. Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. Expression of DDR1/MCK10/CD167 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. DDR1/MCK10/CD167 plays an important role in regulating attachment to collagen, chemotaxis, proliferation, and MMP production in smooth muscle cells. DDR1 functions in a feedforward loop to increase p53 levels and at least some of its effectors. Inhibition of DDR1 function resulted in strikingly increased apoptosis of wild-type p53-containing cells in response to genotoxic stress through a caspase-dependent pathway.