• Antennapedia peptide

Antennapedia peptide

Not For Human Use, Lab Use Only.

Cat.#: 319562

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Optional Service: TFA RemovalWhat's this?

Special Price 143.1 USD

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Product Information

  • Product Name
    Antennapedia peptide
  • Documents
  • Sequence
    H-RQIKIWFQNRRMKWKK-NH2
  • Three letter code
    H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-NH2
  • Length (aa)
    16
  • Peptide Purity (HPLC)
    95.21%
  • Molecular Formula
    C104H169N35O19S
  • Molecular Weight
    2245.74
  • Source
    Synthetic
  • Additional Information
    Antennapedia Peptide (Penetratin peptide, RQIKIWFQNRRMKWKK) is a 16 amino acid residue peptide derived from the homology domain of the 60 amino acid sequence of the Drosophila transcription factor Antennapedia, which is also a membrane-penetrating peptide. Antennapedia Peptide enters cells by different mechanisms, including membrane translocation, thus implying that the peptide interacts with the lipid bilayer. Penetratin also crosses the membrane of artificial vesicles, depending on their phospholipid content.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Jiao CY, Sachon E, Alves ID, Chassaing G, Bolbach G, Sagan S. Exploiting Benzophenone Photoreactivity To Probe the Phospholipid Environment and Insertion Depth of the Cell-Penetrating Peptide Penetratin in Model Membranes. Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8226-8230.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"