Anantin peptide

Anantin peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

GFIGWGNDIFGHYSGDF (Lactam bridge:Gly1-Asp8)

H-Gly-Phe-Ile-Gly-Trp-Gly-Asn-Asp-Ile-Phe-Gly-His-Tyr-Ser-Gly-Asp-Phe-OH (Lactam bridge:Gly1-Asp8)

17

97.8%

C₉₀H₁₁₁N₂₁O₂₄

1870.97

133658-45-4

Synthetic

Powder

Anantin is a cyclic peptide composed of 17 natural L-amino acids, isolated from the bacterium Streptomyces coerulescens. It has a molecular weight of 1,871.0 and a chemical formula of C₉₀H₁₁₁N₂₁O₂₄. The peptide competitively binds to atrial natriuretic factor (ANF) receptors, with a dissociation constant (K_d) of 0.6 µM, and inhibits ANF-induced accumulation of cyclic guanosine monophosphate in bovine aorta smooth muscle cells in a dose-dependent manner. Anantin exhibits no intrinsic agonistic activity, functioning solely as a receptor antagonist.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Weber W, Fischli W, Hochuli E, Kupfer E, Weibel EK. Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). I. Producing organism, fermentation, isolation and biological activity. J Antibiot (Tokyo). 1991 Feb;44(2):164-71. doi: 10.7164/antibiotics.44.164. PMID: 1849131.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.