Alyteserin-2a peptide

Alyteserin-2a peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

ILGKLLSTAAGLLSNL

Ile-Leu-Gly-Lys-Leu-Leu-Ser-Thr-Ala-Ala-Gly-Leu-Leu-Ser-Asn-Leu

16

96.5%

Synthetic

Powder

Active against primarily G+ bacteria such as S. aureus (MIC 50 uM). It is helical in 50% TFE. Three years later, several peptide mutants were made to modulate peptide properties. While increase in cationic amino acids increases antimicrobial activity as well as cytotoxicity, incorporation of D-amino acids improved peptide selectivity (Conlon JM et al., 2012). Updated 11/2012 GW. Alyteserin-2a has Antibacterial activity. Alyteserin-2a was found in the European midwife toad, Alytes obstetricans.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Conlon JM, Demandt A, Nielsen PF, Leprince J, Vaudry H, Woodhams DC. The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). Peptides. 2009;30(6):1069-73.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.