Cart 2
  • alpha-CGRP (23-37) (human) peptide

alpha-CGRP (23-37) (human) peptide

Not For Human Use, Lab Use Only.

Cat.#: 304221

Size:

* Buy 1 get 1 free (?) What is TFA?

Special Price 189.80 USD

Availability: 1-2 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    alpha-CGRP (23-37) (human) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    VKNNFVPTNVGSKAF-NH2
  • Sequence
    H-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
  • Length (aa)
    15
  • Peptide Purity (HPLC)
    96.5%
  • Molecular Formula
    C74H117N21O20
  • Molecular Weight
    1620.87
  • CAS No.
    145459-33-2
  • PubChem CID
    118855743
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Alpha-CGRP (23-37) is a short C-terminal fragment of human calcitonin gene-related peptide (CGRP), consisting of 15 amino acid residues derived from the full-length 37-amino acid neuropeptide. CGRP is a neurotransmitter peptide widely distributed in the central and peripheral nervous system of mammals. The C-terminal region of the CGRP molecule is important for binding to CGRP receptors, but lacks the structural requirements for receptor activation. As a result, CGRP(23-37) functions as a competitive antagonist at CGRP receptors, producing a rightward displacement of the concentration-response curve to human alpha-CGRP without depressing the maximal response. In the guinea pig isolated left atria, this fragment exhibits weak but significant CGRP antagonist activity, with an apparent pA2 value of 4.81.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Rovero P, Giuliani S, Maggi CA. CGRP antagonist activity of short C-terminal fragments of human alpha CGRP, CGRP(23-37) and CGRP(19-37). Peptides. 1992 Sep-Oct;13(5):1025-7. doi: 10.1016/0196-9781(92)90067-d. PMID: 1336185.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"