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Product Name
Human ALDH1A3/RALDH3 (His Tag) recombinant protein
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Description
Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potential clinical prognostic applicability, and demonstrates a clear correlation between CSC prevalence and the development of metastatic breast cancer. The retinoic acid (RA) biosynthesis enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) is a putative androgen-responsive gene in human prostate cancer epithelial (LNCaP) cells. The RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism.
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Protein name
Aldehyde dehydrogenase 1 family, member A3, isoform CRA_a
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Protein short names
ALDH1A3; RALDH-3; ALDH1A6; ALDH6; RALDH3; MCOP8; V1
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Uniprot ID
P47895
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Gene Name
ALDH1A3; hCG_28035
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human ALDH1A3 (NP_000684.2) (Ala 2-Pro 512) was expressed, with a polyhistide tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human ALDH1A3 consisting of 518 amino acids and migrates as an approximately 57 kDa band in SDS-PAGE under reducing conditions as predicted.
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Purity
> 96 % as determined by SDS-PAGE
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Validations
Human ALDH1A3 / RALDH3 Protein (His Tag) SDS-PAGE
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