AGS3 antibody

AGS3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

AGS3 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, human brain tissue, mouse brain tissue, mouse testis tissue. Positive IHC detected in human lung cancer tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 72 kDa

ELISA, IHC, IF, WB

Human,Mouse,Rat; other species not tested.

AGS3 antibody; DKFZp727I051 antibody; GPSM1 antibody

Rabbit IgG

This antibody was obtained by immunization of AGS3 recombinant protein (Accession Number: BC017353). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

GPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate (GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein (p-CREB).