Cart 2
  • Human AK4 / Adenylate Kinase 4 / AK3L1 recombinant protein

Human AK4 / Adenylate Kinase 4 / AK3L1 recombinant protein

Cat.#: 501841


Special Price 532.2 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    Human AK4 / Adenylate Kinase 4 / AK3L1 recombinant protein
  • Documents
  • Description
    Adenylate kinase isoenzyme 4, mitochondrial, also known as ATP-AMP transphosphorylase, Adenylate kinase 3-like, AK4 and AK3L1, is a member the adenylate kinase family. AK4 / AK3L1 is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. AK4 / AK3L1 catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. It may also be active with GTP. Adenylate kinase 4 ( AK4 / AK3L1 ) is a unique member with no enzymatic activity in the adenylate kinase (AK) family although it shares high sequence homology with other AKs. It remains unclear what physiological function AK4 might play or why it is enzymatically inactive. AK4 / AK3L1 retains the capability of binding nucleotides. It has a glutamine residue instead of a key arginine residue in the active site well conserved in other AKs. The enzymatically inactive AK4 is a stress responsive protein critical to cell survival and proliferation. AK4 / AK3L1 is likely that the interaction with the mitochondrial inner membrane protein ANT is important for AK4 to exert the protective benefits to cells under stress. AK4 / AK3L1 also acts on the specific mechanism of energy metabolism rather than control of the homeostasis of the ADP pool ubiquitously.
  • Protein name
    Adenylate kinase 4, mitochondrial
  • Protein short names
    AK4; AK3L1; AK-3; RP4-686B20.1; MGC166959; AK3; AK-4; AK3L2; D4ERTD274E; RP23-301M3.3
  • Uniprot ID
  • Gene Name
    AK4; AK3; AK3L1
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human AK4 (P27144-1) (Ala 2-Tyr 223) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
  • Protein Species
  • Molecular weight
    The secreted recombinant human AK4 consists of 224 amino acids and predicts a molecular mass of 25.3 KDa. The apparent molecular mass of the protein is approximately 27 KDa in SDS-PAGE under reducing conditions due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    Kinase activity untested
  • Validations

    Human AK4 / Adenylate Kinase 4 / AK3L1 Protein SDS-PAGE

    Human AK4 / Adenylate Kinase 4 / AK3L1 Protein SDS-PAGE