Adenylate cyclase-activating peptide-38, PACAP-38
Not For Human Use, Lab Use Only.
Cat.#: 315912
Special Price 480.70 USD
Availability:
4 weeks
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Product Name
Adenylate cyclase-activating peptide-38, PACAP-38
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Documents
Batch to batch variation of the purity
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Sequence Shortening
HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2
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Sequence
His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
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Length (aa)
38
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Peptide Purity (HPLC)
98.3%
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Molecular Formula
C203H331N63O53S
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Molecular Weight
4534.1
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CAS No.
137061-48-4
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PubChem CID
44566111
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Source
Synthetic
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Form
Powder
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Description
Adenylate cyclase-activating peptide-38 (PACAP-38) is a 38-amino acid neuropeptide belonging to the vasoactive intestinal peptide (VIP)-glucagon-growth hormone releasing factor-secretin superfamily. It functions as a signaling molecule in parasympathetic communication and exhibits vasodilatory properties. PACAP-38 activates three G-protein coupled receptors: PAC1, VPAC1, and VPAC2, with a notably higher affinity for the PAC1 receptor compared to VIP.
This neuropeptide is found in the trigeminal ganglion and the sphenopalatine ganglion, positioning it strategically within the trigeminal autonomic reflex pathway. Physiological responses to its administration include marked facial flushing, heat sensation, and increased heart rate. Its role as a vasodilating signaling molecule and its specific receptor activation profile distinguish its functional characteristics from related peptides.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Kimura C, Ohkubo S, Ogi K, et al. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem Biophys Res Commun. 1990;166(1):81-9.
- Vollesen ALH, Snoer A, Chaudhry B, Petersen AS, Hagedorn A, Hoffmann J, Jensen RH, Ashina M. The effect of pituitary adenylate cyclase-activating peptide-38 and vasoactive intestinal peptide in cluster headache. Cephalalgia. 2020 Nov;40(13):1474-1488. doi: 10.1177/0333102420940689. Epub 2020 Sep 22. PMID: 32962406.
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About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"