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  • Acetyl-Amylin (8-37) (human) peptide

Acetyl-Amylin (8-37) (human) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319586

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Optional Service: TFA RemovalWhat's this?

Special Price 275.2 USD

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Product Information

  • Product Name
    Acetyl-Amylin (8-37) (human) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Acetylation-ATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2
  • Sequence
    Acetylation-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2
  • Length (aa)
    30
  • Peptide Purity (HPLC)
    95.77%
  • Molecular Formula
    C140H218N42O46
  • Molecular Weight
    3225.46
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Acetyl-Amylin (8-37) (human) as a peptide fragment of amylin. Acetyl-Amylin (8-37) (human) is a specific amylin antagonist.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Hettiarachchi M, Chalkley S, Furler SM, Choong YS, Heller M, Cooper GJ, Kraegen EW. Rat amylin-(8-37) enhances insulin action and alters lipid metabolism in normal and insulin-resistant rats. Am J Physiol. 1997 Nov;273(5):E859-67. doi: 10.1152/ajpendo.1997.273.5.E859. PMID: 9374670.
    • Villa I, Melzi R, Pagani F, Ravasi F, Rubinacci A, Guidobono F. Effects of calcitonin gene-related peptide and amylin on human osteoblast-like cells proliferation. Eur J Pharmacol. 2000 Dec 15;409(3):273-8. doi: 10.1016/s0014-2999(00)00872-4. PMID: 11108821.
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"