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  • Ac9-25 peptide

Ac9-25 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319851

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Product Information

  • Product Name
    Ac9-25 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Ac-QAWFIENEEQEYVQTVK-OH
  • Sequence
    Ac-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH
  • Length (aa)
    17
  • Peptide Purity (HPLC)
    97.28%
  • Molecular Formula
    C99H143N23O33
  • Molecular Weight
    2183.36
  • CAS No.
    284040-76-2
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The Ac9-25 peptide is a synthetic fragment derived from the N-terminal region of annexin A1, spanning amino acids 9 to 25. This peptide exhibits dual functionality in neutrophil signaling, activating the NADPH-oxidase through the formyl peptide receptor (FPR), but not through FPR-like 1 (FPRL1). The activation mechanism involves G protein-coupled receptor signaling, leading to superoxide anion release. Concurrently, Ac9-25 generates an inhibitory signal that suppresses NADPH-oxidase activity triggered by various chemoattractants, operating through a distinct receptor independent of the FPR family.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Walther A, Riehemann K, Gerke V. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000 May;5(5):831-40. doi: 10.1016/s1097-2765(00)80323-8. PMID: 10882119.
    • Karlsson J, Fu H, Boulay F, Dahlgren C, Hellstrand K, Movitz C. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol. 2005 Sep;78(3):762-71. doi: 10.1189/jlb.0305153. Epub 2005 Jun 10. PMID: 15951351.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"