Ac2-26 peptide
Not For Human Use, Lab Use Only.
Cat.#: 318967
Special Price 212.4 USD
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Product Name
Ac2-26 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
Ac-AMVSEFLKQAWFIENEEQEYVQTVK-OH
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Sequence
Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH
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Length (aa)
25
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Peptide Purity (HPLC)
95.95%
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Molecular Formula
C141H210N32O44S
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Molecular Weight
3089.41
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Source
Synthetic
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Form
Powder
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Description
Ac2-26 is the N terminal fragment of annexin A1 and an annexin/lipocortin 1 mimetic. Ac2-26 can inhibit leukocyte extravasation, reduce neutrophil adhesion and emigration, promote detachment of neutrophils from activated mesenteric endothelium and accelerate epithelial wound repair. Local intestinal delivery of Ac2-26 encapsulated within targeted polymeric nanoparticles accelerates healing of murine colonic wounds after biopsy-induced injury.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Perretti and Gavins (2003) Annexin 1: an endogenous anti-inflammatory protein. News Physiol.Sci. 18 60 PMID: 12644621
- Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J.Clin.Invest. 125 1215 PMID: 25664854
- Possebon et al (2018) Mimetic peptide AC2-26 of annexin A1 as a potential therapeutic agent to treat COPD, International Immunopharmacology, 63 270 PMID: 30121452
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"