Ac-rER peptide
Not For Human Use, Lab Use Only.
Cat.#: 319493
Special Price 94.2 USD
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Product Name
Ac-rER peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
Ac-rER, r=D-Arg
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Sequence
Ac-D-Arg-Glu-Arg-OH
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Length (aa)
3
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Peptide Purity (HPLC)
95.35%
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Molecular Formula
C19H35N9O7
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Molecular Weight
501.53
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Source
Synthetic
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Form
Powder
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Description
Injected intracerebrally around the time of training, RER not only protects against the amnestic effects of down-regulating or functionally blocking APP(amyloid precursor protein), but also against the amnestic effect of the amyloidogenic peptide Aβ1–42. RER binds to proteins at 65–69 kDa, and the binding can be displaced by sAPP fragments. Acetylated-rER (Ac-rER, where the lower case indicates the D-isomeric form of the amino acid), is rapidly transported across the blood-brain-barrier, protects against Aβ-induced memory loss and enhances retention when injected peripherally up to 12 h prior to training.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Mileusnic R, Rose SP. The memory enhancing effect of the APP-derived tripeptide Ac-rER is mediated through CRMP2. J Neurochem. 2011 Aug;118(4):616-25. doi: 10.1111/j.1471-4159.2011.07193.x. Epub 2011 Feb 24. PMID: 21255016.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"