3BP-3940 peptide
Not For Human Use, Lab Use Only.
Cat.#: 319671
Special Price 1199.0 USD
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Product Name
3BP-3940 peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
nBu-CAyl-[Cys(tMeBn(DOTA-AET)-PPTQFC]-OH
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Sequence
nBu-CAyl-[Cys(tMeBn(DOTA-AET)-Pro-Pro-Thr-GIn-Phe-Cys]-OH
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Length (aa)
7
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Peptide Purity (HPLC)
95.45%
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Molecular Formula
C66H98N14O18S3
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Molecular Weight
1471.76
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CAS No.
2803421-14-7
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PubChem CID
168830803
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Source
Synthetic
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Form
Powder
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Description
3BP-3940 is a highly potent peptide developed for targeting fibroblast activation protein (FAP), which is commonly expressed in the tumor microenvironment of various solid cancers. The peptide is designed for use in theranostics, combining diagnostic and therapeutic applications. It can be labeled with radionuclides like Gallium-68 (Ga-68) for imaging purposes and Lutetium-177 (Lu-177) for therapy. 3BP-3940 has been optimized for prolonged tumor retention and low uptake in healthy tissues, addressing a major challenge with other FAP-targeting compounds that show rapid clearance from tumors. The development of 3BP-3940 includes automated manufacturing processes and radiolabeling methods, ensuring high purity and stability for clinical use. Initial studies have demonstrated promising results in terms of diagnostic imaging and therapeutic effectiveness in cancer patients.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
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References
- Greifenstein L, Gunkel A, Hoehne A, Osterkamp F, Smerling C, Landvogt C, Mueller C, Baum RP. 3BP-3940, a highly potent FAP-targeting peptide for theranostics - production, validation and first in human experience with Ga-68 and Lu-177. iScience. 2023 Nov 23;26(12):108541. doi: 10.1016/j.isci.2023.108541. PMID: 38089587; PMCID: PMC10711456.
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About TFA salt
Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.
TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.
TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.
In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"