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  • 1037 peptide

1037 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319849

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* Buy 1 get 1 free (?) What is TFA?

Special Price 101.70 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    1037 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-KRFRIRVRV-NH2
  • Sequence
    H-Lys-Arg-Phe-Arg-Ile-Arg-Val-Arg-Val-NH2
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.74%
  • Molecular Formula
    C55H101N23O9
  • Molecular Weight
    1228.54
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Peptide 1037 is a small synthetic cationic peptide with the amino acid sequence KRFRIRVRV-NH2. It belongs to the class of cationic antimicrobial peptides (CAMPs), which are characterized by their ability to interact with bacterial membranes through electrostatic and hydrophobic interactions. The peptide was modified by introducing a cysteine residue at its N-terminus, leading to the spontaneous formation of a dimer through a disulfide bond. This dimerization significantly enhanced the peptide's antimicrobial activity, demonstrating a 60-fold increase in efficacy against certain bacterial strains compared to the monomeric form.

    The dimer retains the structural and functional properties of the original peptide, including its cationic and amphiphilic characteristics, which facilitate membrane interactions. The modification and dimerization process did not compromise the peptide's inherent bioactivity, as it maintained its ability to interact with microbial membranes and inhibit bacterial growth. This approach highlights the potential of strategic peptide modifications to amplify antimicrobial properties while preserving core functional attributes.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Thamri A, Létourneau M, Djoboulian A, Chatenet D, Déziel E, Castonguay A, Perreault J. Peptide modification results in the formation of a dimer with a 60-fold enhanced antimicrobial activity. PLoS One. 2017 Mar 15;12(3):e0173783. doi: 10.1371/journal.pone.0173783. PMID: 28296935; PMCID: PMC5351969.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"