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  • 1018M peptide

1018M peptide

Not For Human Use, Lab Use Only.

Cat.#: 319848

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Special Price 132.10 USD

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Product Information

  • Product Name
    1018M peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-VRLRWWRRRWRR-NH2
  • Sequence
    H-Val-Arg-Leu-Arg-Trp-Trp-Arg-Arg-Arg-Trp-Arg-Arg-NH2
  • Length (aa)
    12
  • Peptide Purity (HPLC)
    98.24%
  • Molecular Formula
    C86H137N37O12
  • Molecular Weight
    1881.24
  • Source
    Synthetic
  • Form
    Powder
  • Description

    1018M is a novel antimicrobial peptide designed through molecular docking and amino acid substitution based on the innate defense regulator peptide IDR-1018. It features an α-helix structure and exhibits enhanced physicochemical properties, including a higher positive charge and isoelectric point compared to its parental peptide. The peptide demonstrates strong binding affinity to the stringent response signaling molecule ppGpp, forming multiple hydrogen bonds through specific amino acid residues.

    This peptide effectively disrupts bacterial cell walls and permeabilizes cell membranes, leading to significant structural damage and content leakage. Additionally, 1018M interacts with bacterial genomic DNA and regulates the expression of genes related to ppGpp metabolism and biofilm formation. It displays improved stability under varying temperatures, pH conditions, and protease exposure, contributing to its robust antimicrobial and anti-biofilm activities.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Jiale Z, Jian J, Xinyi T, Haoji X, Xueqin H, Xiao W. Design of a novel antimicrobial peptide 1018M targeted ppGpp to inhibit MRSA biofilm formation. AMB Express. 2021 Mar 26;11(1):49. doi: 10.1186/s13568-021-01208-6. PMID: 33770266; PMCID: PMC7997937.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"