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  • [Pyr1]-Apelin 13 peptide

[Pyr1]-Apelin 13 peptide

Not For Human Use, Lab Use Only.

Cat.#: 319070

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Product Information

  • Product Name
    [Pyr1]-Apelin 13 peptide
  • Documents
  • Sequence Shortening
    Pyr-RPRLSHKGPMPF-OH
  • Sequence
    Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
  • Length (aa)
    12
  • Peptide Purity (HPLC)
    95.01%
  • Molecular Formula
    C69H108N22O16S
  • Molecular Weight
    1533.79
  • Source
    Synthetic
  • Form
    Powder
  • Description
    [Pyr1]-Apelin 13 or [pGlu1]-apelin-13 is a highly potent pyroglutamyl form of apelin 13 which acts as the endogenous ligand for the apelin APJ receptor, with an EC50 of 0.37 nM. [Pyr1]-Apelin 13 is the predominant isoform detected in human heart and plasma and acts as a potent inotropic agent and vasodilator.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471 PMID: 9792798
    • Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343
    • Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. TiPS 36(9) 560 PMID: 26143239
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"