(NANP)3 peptide

(NANP)3 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-NANPNANPNANP-OH

H-Asn-Ala-Asn-Pro-Asn-Ala-Asn-Pro-Asn-Ala-Asn-Pro-OH

12

95.12%

C₄₈H₇₄N₁₈O₁₉

1207.2

Synthetic

Powder

(NANP)3 polypeptide is a crucial peptide sequence in the field of malaria research. It is a tandem repeat peptide with the structure NANPNANPNANP, derived from the circumsporozoite (CS) protein of Plasmodium falciparum. This polypeptide serves as a significant protective epitope. Antibodies against (NANP)3 play a vital role in inhibiting the motility of sporozoites, thereby preventing the invasion of host hepatocytes and subsequent blood-stage infection. It has been widely utilized in the development of various malaria vaccine candidates, including synthetic peptides, multiple antigenic peptides (MAPs), polyoxime branched peptides, and virus-like particles (VLPs). The immunogenicity of (NANP)3 makes it a key target for inducing immune responses against malaria, holding great potential in the fight against this deadly disease.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Rudra JS, Mishra S, Chong AS, Mitchell RA, Nardin EH, Nussenzweig V, Collier JH. Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope. Biomaterials. 2012 Sep;33(27):6476-84. doi: 10.1016/j.biomaterials.2012.05.041. Epub 2012 Jun 12. PMID: 22695068; PMCID: PMC3392361.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.