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Product Name
Cynomolgus EDAR/Ectodysplasin A Receptor (His Tag) recombinant protein
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Description
Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
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Protein name
Uncharacterized protein
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Protein short names
ED5; ECTD10A; EDA3; FLJ94390; EDA1R; ECTD10B; ED1R; HRM1; EDA-A1R; DL; ED3; EDAR
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Uniprot ID
F7GZI3
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Gene Name
EDAR
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus EDAR (F7GZI3) (Met1-Ala187) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus EDAR comprises 172 amino acids and has a calculated molecular mass of 18.8 KDa. The apparent molecular mass of it is approximately 30-40 KDa respectively in SDS-PAGE.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Cynomolgus EDAR Protein (His Tag) SDS-PAGE
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