Human RELT/TNFRSF19L (His Tag) recombinant protein

Human RELT/TNFRSF19L (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Receptor expressed in lymphoid tissues (RELT), also known as tumor necrosis factor receptor superfamily, member 19-like (TNFRSF19L), is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. RELT/TNFRSF19L is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain, possessing significant homology to other members of the TNFR superfamily, especially TNFRSF19, DR3, OX40, and LTbeta receptor. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. RELT/TNFRSF19L is able to activate the NF-κB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction, immobilized RELT/TNFRSF19L is capable of costimulating T-cell proliferation in the presence of CD3 signaling.

Tumor necrosis factor receptor superfamily, member 19-like, isoform CRA_b

E430021K24RIK; FLJ14993; TNFRSF19L; TRLT; RELT

Q969Z4

TNFRSF19L; hCG_23330

Human Cells

A DNA sequence encoding the human RELT (NP_116260.2) extracellular domain (Met 1-Ala 160) was fused with a polyhistidine tag at the C-terminus, with 127R/G & 129R/G mutations.

Human

The recombinant human RELT consists of 146 amino acids and has a predicted molecular mass of 15.7 kDa. As a result of glycosylation, the apparent molecular mass of rhRELT is approximately 25-30 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE