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Product Name
Cynomolgus EWI-F / PTGFRN (His Tag) recombinant protein
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Description
EWI-F, also known as PTGFRN, is inversely related to the loss of CD9. Its expression correlates with the metastatic status of hLT (n=55). EWI-F inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. EWI-F expression positively correlates with the metastatic status of hLT, and that the upregulation of EWI-F expression could be one of the mechanisms underlying the loss of CD9 in solid tumours.
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Protein name
Prostaglandin F2 receptor negative regulator
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Protein short names
CD9P-1; FPRP; PROSTAGLANDIN F2 RECEPTOR INHIBITOR; 4833445A08RIK; PROSTAGLANDIN F2-ALPHA RECEPTOR-ASSOCIATED PROTEIN; PTGFRN; DN-358O3.4; TRIM45; EWI-F; PROSTAGLANDIN F2-ALPHA RECEPTOR REGULATORY PROTEIN; GLU-TRP-ILE EWI MOTIF-CONTAINING PROTEIN F; SMAP-6; CD315; AU042434; CD9 PARTNER 1; PROSTAGLANDIN F2 RECEPTOR NEGATIVE REGULATOR
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Uniprot ID
H9ERH4
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Gene Name
PTGFRN
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus PTGFRN (H9ERH4) (Met1-Lys830) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Cynomolgus
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Molecular weight
The recombinant cynomolgus PTGFRN comprises 816 amino acids and has a calculated molecular mass of 91.5 KDa. The apparent molecular mass of it is approximately 96-106 KDa in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Cynomolgus EWI-F / PTGFRN Protein (His Tag) SDS-PAGE
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