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Product Name
Human CD111/Nectin-1/PVRL1 (His Tag) recombinant protein
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Description
Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between PVRL1/nectin-1 and PVRL3/nectin-3 and between PVRL1/nectin-1 and PVRL4/nectin-4. Functions as an entry receptor for herpes simplex virus and pseudorabies virus. Has some neurite outgrowth-promoting activity.
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Protein name
Nectin-1
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Protein short names
PRR1; PVRR1; CLPED1; PVRL1; HV1S; CD111; NECTIN-1; PRR; OFC7; HIGR; AW549174; MGC16207; PVRR; MGC142031; HVEC; AI835281; ED4; SK-12
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Uniprot ID
Q15223
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Gene Name
PVRL1; HVEC; PRR1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human PVRL1 isoform 1 (NP_002846.3) extracellular domain (Met 1-Thr 334) was expressed, with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human PVRL1 consists of 315 amino acids and predictes a molecular mass of 35.4 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhPVRL1 is approximately 45-50 kDa due to glycosylation.
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Purity
> 98 % as determined by SDS-PAGE
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Activity
Measured by its binding ability in a functional ELISA. Immobilized PVRL3 at 1 μg/ml (100 μl/well) can bind biotinylated recombinant human PVRL1 / Nectin-1 with a linear range of 6.4-800 ng/ml.
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Validations
Human CD111 / Nectin-1 / PVRL1 Protein (His Tag) SDS-PAGE
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