Human WDYHV1/C8orf32/NTAQ1 recombinant protein

Human WDYHV1/C8orf32/NTAQ1 recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Human protein N-terminal glutamine amidohydrolase (WDYHV1) is an enzyme that in humans is encoded by the WDYHV1 gene, belongs to the NTAQ1 family.WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, which is an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. However,it does not act on substrates with internal or C-terminal glutamine andnon-glutamine residues in any position. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.

WDYHV motif containing 1(WDYHV1)

C8orf32; NTAQ1

Q96HA8

E. coli

A DNA sequence encoding the Human WDYHV1/C8orf32/NTAQ1 Met1-Cys205 is expressed with a GST tag at the N-terminus.

Human

>95% as determined by SDS-PAGE.