Human RAMP3 (Fc Tag) recombinant protein

Human RAMP3 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

RAMP3 belongs to the RAMP family. Members of this family are single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. They are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of RAMP3 protein, CRLR functions as an adrenomedullin receptor.

CALCITONIN RECEPTOR-LIKE RECEPTOR ACTIVITY MODIFYING PROTEIN 3; RECEPTOR (G PROTEIN-COUPLED) ACTIVITY MODIFYING PROTEIN 3; RP23-169J19.5; RAMP3; RECEPTOR (CALCITONIN) ACTIVITY MODIFYING PROTEIN 3; RECEPTOR ACTIVITY-MODIFYING PROTEIN 3; AI850306; CRLR ACTIVITY-MODIFYING PROTEIN 3; RECEPTOR ACTIVITY MODIFYING PROTEIN 3

Human Cells

A DNA sequence encoding the human RAMP3 (Met1-Val118) was expressed with the Fc region of human IgG1 at the C-terminus.

Human

The recombinant human RAMP3 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 336 amino acids and has a predicted molecular mass of 37.8 kDa. The apparent molecular mass of the protein is approximately 28-31 kDa in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE