Human PRMT7 Recombinant protein (His tag)

Human PRMT7 Recombinant protein (His tag)

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Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. {PubMed:15044439, PubMed:15494416, PubMed:17709427, PubMed:19110445}.

Protein arginine N-methyltransferase 7

KIAA1933

A0A8I5KYD6

PRMT7; KIAA1933

E. coli

A DNA sequence encoding the human PRMT7 (XP_016878781.1) 353-686 aa was fused with the polyhistidine tag

Human

Not tested.