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Product Name
Human IL-1R9/IL1RAPL2 (Fc Tag) recombinant protein
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Description
X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in fetal brain and is highly homologous to IL1RAPL, which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptor are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci, and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.
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Protein name
X-linked interleukin-1 receptor accessory protein-like 2
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Protein short names
TIGIRR-1; IL1R9; IL1RAPL-2; ILRAPL2; IL-1R9
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Uniprot ID
Q9NP60
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Gene Name
IL1RAPL2; IL1R9
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the extracellular domain (Met 1-Glu 356) of human IL1R9 (NP_059112.1) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human IL1R9/Fc is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The reduced monomer consists of 578 amino acids and has a predicted molecular mass of 66 kDa. In SDS-PAGE, the apparent molecular mass of rhIL1R9/Fc monomer is approximately 80-85 kDa due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human IL-1R9 / IL1RAPL2 Protein (Fc Tag) SDS-PAGE
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