Human IL-1R9/IL1RAPL2 (Fc Tag) recombinant protein

Cat.#: 503747

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Product Information

  • Product Name
    Human IL-1R9/IL1RAPL2 (Fc Tag) recombinant protein
  • Documents
  • Description
    X-linked interleukin-1 receptor accessory protein-like 2 (IL1RAPL2) or Interleukin-1 receptor 9 (IL-1R9) is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins. IL-1R9/IL1RAPL2 shows restricted expression in fetal brain and is highly homologous to IL1RAPL, which is reportedly involved in nonsyndromic X-linked mental retardation. IL-1R9/IL1RAPL2 is highly homologous to IL-1R8. Both forms have no known ligands and receptor are found in the fetal brain. IL-1R9/IL1RAPL2 may function as a negative receptor. Both IL1RAPL1 and IL1RAPL2 have novel C-terminal sequences not present in other related proteins. IL-1R9/IL1RAPL2 may be strong candidates for X-linked non-syndromic mental retardation loci, and that molecules resembling IL-1 and IL-18 play a role in the development or function of the central nervous system.
  • Protein name
    X-linked interleukin-1 receptor accessory protein-like 2
  • Protein short names
    TIGIRR-1; IL1R9; IL1RAPL-2; ILRAPL2; IL-1R9
  • Uniprot ID
    Q9NP60
  • Gene Name
    IL1RAPL2; IL1R9
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the extracellular domain (Met 1-Glu 356) of human IL1R9 (NP_059112.1) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human IL1R9/Fc is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The reduced monomer consists of 578 amino acids and has a predicted molecular mass of 66 kDa. In SDS-PAGE, the apparent molecular mass of rhIL1R9/Fc monomer is approximately 80-85 kDa due to glycosylation.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Validations

    Human IL-1R9 / IL1RAPL2 Protein (Fc Tag) SDS-PAGE

    Human IL-1R9 / IL1RAPL2 Protein (Fc Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"