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Product Name
Human CARKL / SHPK recombinant protein
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Description
CARKL, also known as SHPK, is a nonprotein kinase of glucose metabolism. CARKL has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. CARKL catalyzes an orphan reaction in the pentose phosphate pathway, refocusing cellular metabolism to a high-redox state upon physiological or artificial downregulation. CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization and uncover a rate-limiting requirement for appropriate glucose flux in macrophage polarization.
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Protein name
Transient receptor potential cation channel subfamily V member 1
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Protein short names
AI194947; SHPK; AW260459; RP23-214D6.1; 4930431K22RIK; CARBOHYDRATE KINASE-LIKE PROTEIN; SHK; CARKL; SEDOHEPTULOKINASE
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Uniprot ID
Q9UHJ6
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Gene Name
TRPV1
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human SHPK (NP_037408.2) (Ala2-Ser478) was fused with two additional amino acids (Gly&Pro) at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human SHPK consists of 479 amino acids and has a calculated molecular mass of 51.5 kDa. The recombinant protein migrates as an approximately 47 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 85 % as determined by SDS-PAGE
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Activity
Kinase activity untested
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Validations
Human CARKL / SHPK Protein SDS-PAGE
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