Human CALR3/CRT2 recombinant protein

Human CALR3/CRT2 recombinant protein

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Calreticulin-3 belongs to the calreticulin family, members of which are calcium binding chaperones localized mainly in the endoplasmic reticulum. It can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. During spermatogenesis process, Calreticulin-3 may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19), it is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain.

calreticulin 3(CALR3)

CRT2

Q96L12

E.coli

A DNA sequence encoding the Human CALR3/CRT2 Thr20-Leu384 is expressed.

Human

>95% as determined by SDS-PAGE.