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Product Name
Human B3GALTL (His Tag) recombinant protein
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Description
B3GALTL is a beta-1,3-glucosyltransferase that transfers glucose to O-linked fucosylglycans on thrombospondin type-1 repeats (TSRs) of several proteins. B3GALTL is a type II membrane protein. Defects in B3GALTL gene are a cause of Peters-plus syndrome (PPS). As an O-fucosyltransferase, B3GALTL transfers glucose toward fucose with a beta-1,3 linkage. It specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan.
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Protein short names
B3GLCT; BETA-3-GLYCOSYLTRANSFERASE-LIKE; BETA3GLC-T; BETA 1; 3-GLUCOSYLTRANSFERASE; B3GTL; 3-GALACTOSYLTRANSFERASE-LIKE; 3-GALACTOSYLTRANSFERASE-LIKE; B3GALTL; BETA 3-GLYCOSYLTRANSFERASE-LIKE; B3GLC-T; UDP-GAL:BETA-GLCNAC BETA-1; GAL-T; RP11-367C11.1; GM1057; BETA-1
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human B3GALTL (Ser29-Phe494) was expressed with an N-terminal polyhistidine tag.
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Protein Species
Human
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Molecular weight
The recombinant human B3GALTL comprises 486 amino acids and has a predicted molecular mass of 55.4 kDa. The apparent molecular mass of the protein is approximately 54 kDa in SDS-PAGE under reducing conditions due to glycosylation.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human B3GALTL Protein (His Tag) SDS-PAGE
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