• D-4F peptide

D-4F peptide

Not For Human Use, Lab Use Only.

Cat.#: 319302

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Optional Service: TFA RemovalWhat's this?

Special Price 152.9 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    D-4F peptide
  • Documents
  • Sequence
    Ac-DWFKAFYDKVAEKFKEAF-NH2
  • Three letter code
    Ac-Asp-Trp-Phe-Lys-Ala-Phe-Tyr-Asp-Lys-Val-Ala-Glu-Lys-Phe-Lys-Glu-Ala-Phe-NH2
  • Length (aa)
    18
  • Peptide Purity (HPLC)
    95.48%
  • Molecular Formula
    C114H156N24O28
  • Molecular Weight
    2310.59
  • Source
    Synthetic
  • Additional Information
    D-4F is a type of apolipoprotein mimetic peptide discussed in the paper. The peptide is synthesized from all D-amino acids and has been shown to improve lipoprotein inflammatory properties and ameliorate atherosclerosis in mouse models. When compared to L-4F, D-4F was found to be equally efficacious in reducing atherosclerosis and inflammation after subcutaneous injection in cholesterol-fed rabbits.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Navab M, Ruchala P, Waring AJ, Lehrer RI, Hama S, Hough G, Palgunachari MN, Anantharamaiah GM, Fogelman AM. A novel method for oral delivery of apolipoprotein mimetic peptides synthesized from all L-amino acids. J Lipid Res. 2009 Aug;50(8):1538-47. doi: 10.1194/jlr.M800539-JLR200. Epub 2009 Feb 18. PMID: 19225094; PMCID: PMC2724044.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"