Cynomolgus ICOSLG recombinant protein (C-human IgG1-Fc)

Cynomolgus ICOSLG recombinant protein (C-human IgG1-Fc)

• DataSheet
• Material Safety Data Sheets (MSDS)

Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.Immune Checkpoint
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A0A1D5Q2R9

Human Cells

A DNA sequence encoding the cynomolgus ICOSLG (XP_005548617.1) (Met1-Thr256) was expressed with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus ICOSLG consists of 476 amino acids and predicts a molecular mass of 53.3 kDa.

> 95 % as determined by SDS-PAGE.