-
Product Name
Cynomolgus ICOS Ligand/B7-H2 (His Tag) recombinant protein
- Documents
-
Description
Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.
-
Protein short names
B7-H2; ICOS-L; KIAA0653; CD275; AU044799; B7RP-1; B7H; ICOSL; B7RP1; MKIAA0653; GL50; B7H2; ICOS LIGAND; GI50; LY115L; LICOS; BG071784; GL50-B; ICOSLG
-
Uniprot ID
H9Z6Y0
-
Source/Expression Host
Human Cells
-
Expression Plasmid/cDNA
A DNA sequence encoding the cynomolgus ICOSLG (XP_005548618.1) (Met1-Thr256) was expressed with a polyhistidine tag at the C-terminus.
-
Protein Species
Cynomolgus
-
Molecular weight
The recombinant cynomolgus ICOSLG consists 249 amino acids and predicts a molecular mass of 28.1 kDa.
-
Purity
> 95 % as determined by SDS-PAGE.
-
Validations
Cynomolgus ICOS Ligand / B7-H2 / ICOSLG Protein (His Tag)
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"