Cynomolgus Fractalkine/CX3CL1 (Fc Tag) recombinant protein

Cynomolgus Fractalkine/CX3CL1 (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine / CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine / CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.

C-X3-C motif chemokine 1

AB030188; NTN; SCYD1; CX3CL1; NEUROTACTIN; NTT; FRACTALKINE; AI848747; D8BWG0439E; ABCD-3; CXC3C; C3XKINE; CX3C; CXC3

G7Q177

EGM_11771

Human Cells

A DNA sequence encoding the cynomolgus CX3CL1 (EHH60415.1) (Met1-Gly100) was expressed with the Fc region of human IgG1 at the C-terminus. Cynomolgus and Rhesus CX3CL1 sequences are identical.

Cynomolgus

The recombinant cynomolgus CX3CL1 comprises 317 amino acids and has a calculated molecular mass of 35.7 KDa. The apparent molecular mass of it is approximately 40.8 and 35.2 KDa respectively in SDS-PAGE under reducing conditions.

(90.9+6.8) % as determined by SDS-PAGE