Cynomolgus EGFR recombinant protein (C-His)
As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Epidermal growth factor receptor
Epidermal growth factor receptor; EC 220.127.116.11
A DNA sequence encoding the cynomolgus EGFR (XP_005549616.1) (Met1-Ser645) was expressed with a polyhistidine tag at the C-terminus.
The recombinant cynomolgus EGFR consists of 632 amino acids and predicts a molecular mass of 70.1 kDa.
> 90 % as determined by SDS-PAGE.
Cynomolgus EGFR/HER1 Protein 14108
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