Cynomolgus EDAR/Ectodysplasin A Receptor (Fc Tag) recombinant protein

Cynomolgus EDAR/Ectodysplasin A Receptor (Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

EDA-A1R; HRM1; EDAR; ED3; DL; FLJ94390; EDA3; ECTD10A; ED5; ED1R; ECTD10B; EDA1R

Human Cells

A DNA sequence encoding the cynomolgus EDAR (Met1-Ala187) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Cynomolgus

The recombinant cynomolgus EDAR is a disulfide-linked homodimer. The reduced monomer comprises 404 amino acids and has a calculated molecular mass of 44.6 KDa.The apparent molecular mass of the protein is approximately 60-64 KDa respectively in SDS-PAGE.

> 95 % as determined by SDS-PAGE