AES16-2M peptide

AES16-2M peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

1 Vial

H-REGRT-OH

H-Arg-Glu-Gly-Arg-Thr-OH

5

95.99%

C₂₃H₄₃N₁₁O₉

617.65

Synthetic

AES16-2M peptide is a small wound healing peptide with a sequence of REGRT. AES16-2M was shown to induce ERK activation in keratinocytes and enhanced wound repair which is comparable to the respective effects of TGFβ and EGF. AES16-2M significantly reduced the dermatitis score, ear thickness, and the level of blood IgE and TSLP in AD mice. AES16-2M could be a novel candidate for AD(atopic dermatitis) treatment.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides

• Kim MS, Song J, Park S, Kim TS, Park HJ, Cho D. The Wound Healing Peptide, AES16-2M, Ameliorates Atopic Dermatitis In Vivo. Molecules. 2021 Feb 22;26(4):1168.

Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

TFA Removal Service is recommended for:

• Peptides that will be used in cellular assays
• Peptides that will be used as APIs or in manufactured products
• For hydrophilic peptides containing numerous basic residues