• topII 828-836 (HLA-A*02:01) peptide

topII 828-836 (HLA-A*02:01) peptide

Not For Human Use, Lab Use Only.

Cat.#: 319273

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Optional Service: TFA RemovalWhat's this?

Special Price 94.2 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    topII 828-836 (HLA-A*02:01) peptide
  • Documents
  • Sequence
    H-FLYDDNQRV-OH
  • Three letter code
    H-Phe-Leu-Tyr-Asp-Asp-Asn-Gln-Arg-Val-OH
  • Length (aa)
    9
  • Peptide Purity (HPLC)
    95.77%
  • Molecular Formula
    C52H76N14O17
  • Molecular Weight
    1169.24
  • Source
    Synthetic
  • Additional Information
    FLYDDNQRV is a linear peptidic epitope (epitope ID193822) studied as part of DNA topoisomerase 2-beta from Homo sapiens (human) and DNA topoisomerase 2-alpha from Homo sapiens (human). This epitope has been studied for immune reactivity, tested in MHC ligand assays
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Venkatesh Ramakrishna and others, Naturally occurring peptides associated with HLA‐A2 in ovarian cancer cell lines identified by mass spectrometry are targets of HLA‐A2‐restricted cytotoxic T cells, International Immunology, Volume 15, Issue 6, June 2003, Pages 751–763, https://doi.org/10.1093/intimm/dxg074
  • About TFA salt

    Trifluoroacetic acid (TFA) is a strong acid, which is commonly used to cleave synthesized peptides from solid-phase resins and is also used to improve HPLC performance in the peptide purification step. By default, custom peptides are delivered as lyophilized TFA salts, and can contain as much as 10-45% TFA.

    TFA in custom peptides can cause inexplicable discrepancies in subsequent assay data. For instance, TFA in nM concentrations has been shown to interfere with cellular assays, inhibiting cellular proliferation in some instances, and increasing cell viability in others . It has also been found to be an unintended allosteric modulator of the glycine receptor, GlyR.

    TFA Removal Service is recommended for:

    • Peptides that will be used in cellular assays
    • Peptides that will be used as APIs or in manufactured products
    • For hydrophilic peptides containing numerous basic residues

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"