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Mammals have evolved complex nutrient response pathways that link external energy sources with internal metabolic homeostasis. Among these, β-hydroxybutyrate (BHB) is a crucial metabolite whose levels increase when there is insufficient carbohydrate...

Typically, TEV protease is thought to require Glycine (Gly) or Serine (Ser) at the P1' position for effective cleavage, but this could lead to non-native residues being present on the N-terminus after tag removal, potentially affecting protein a...

The TetR protein primarily functions as a transcriptional repressor regulating tetracycline resistance genes, especially those that encode efflux pumps like TetA. Its main functions are:Regulation of Efflux Genes: TetR binds to the operator region of...

Chemical genetics refers to the modification of biological macromolecules to interact with previously unrecognized small molecules, thereby achieving controlled and reversible (initiating or interrupting specific reactions with the addition or remova...

When studying gene function, a common approach is to reduce or block gene expression and then analyze the phenotype. For over a decade, RNA interference (RNAi) has been the king in this field. However, the emergence of new technologies, especially C...

A transposon, also known as a transposable element or jumping gene, is a DNA sequence that can change its position within the genome. Sometimes, it creates or reverses mutations that alter the genetic characteristics of cells and the size of the gen...

The RNA polymerase Pol III uniquely transcribes small noncoding RNAs, including 5S rRNAs (type 1), tRNAs (type 2), and a number of other small RNAs (type 3), such as U6 snRNA. Pol III promoters can be divided into three types: type 1 and type 2 and ...

1. DOTA Original Name: 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid Molecular Structure: Metals for Chelation: 52Mn, 55Co, 64Cu, 66Ga, 86Y, 89Zr, 152Tb Literature References: 64Cu, 68Ga, 111In, 177Lu Redox Potential: -0.74 (irreversible)...

Based on their structure, detergents can be broadly classified as: Ionic, Zwitterionic and Non-ionic. Ionic detergents contain anionic or cationic head groups and possess a net charge. The size of an ionic detergent micelle is determined by the comb...

Mouse hover on the 'Description' column to view the full text.AbbreviationStands ForAlso Known AsDescription1-Nalβ-(1-Naphthyl)-L-alanine3-(1-Naphthyl)-L-alanineA non-natural amino acid shown to be a useful building block in the synthesis of peptides...