TICAM1 Polyclonal Antibody
Polyclonal antibody to TICAM1
Human, Mouse, Rat
TICAM1 antibody; IIAE6 antibody; MyD88-3 antibody; PRVTIRB antibody; TICAM-1 antibody; TRIF antibody; toll like receptor adaptor molecule 1 antibody
Antigen: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TICAM1 (NP_891549.1).
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
WB 1:500 - 1:2000
Western blot - TICAM1 Polyclonal Antibody
Western blot analysis of extracts of SKOV3 cells, using TICAM1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit .Exposure time: 1s.
Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines (By similarity).
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