Polyclonal antibody to Phospho-PTPN6-Y536
Human, Mouse, Rat
PTPN6 antibody; HCP antibody; HCPH antibody; HPTP1C antibody; PTP-1C antibody; SH-PTP1 antibody; SHP-1 antibody; SHP-1L antibody; SHP1 antibody; tyrosine-protein phosphatase non-receptor type 6 antibody
Antigen: A phospho specific peptide corresponding to residues surrounding Y536 of human PTPN6
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
IHC 1:50 - 1:100
IF 1:100 - 1:200
Immunohistochemistry - Phospho-PTPN6-Y536 pAb
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue, using Phospho-PTPN6-Y536 antibody .
Immunofluorescence - Phospho-PTPN6-Y536 pAb
Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-PTPN6-Y536 antibody .
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
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