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Product Name
Phospho-PTPN6-Y536 pAb
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Description
Polyclonal antibody to Phospho-PTPN6-Y536
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Tested applications
IHC, IF
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Species reactivity
Human, Mouse, Rat
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Alternative names
PTPN6 antibody; HCP antibody; HCPH antibody; HPTP1C antibody; PTP-1C antibody; SH-PTP1 antibody; SHP-1 antibody; SHP-1L antibody; SHP1 antibody; tyrosine-protein phosphatase non-receptor type 6 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: A phospho specific peptide corresponding to residues surrounding Y536 of human PTPN6
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
IHC 1:50 - 1:100
IF 1:100 - 1:200 -
Validations
Immunohistochemistry - Phospho-PTPN6-Y536 pAb
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue, using Phospho-PTPN6-Y536 antibody .
Immunofluorescence - Phospho-PTPN6-Y536 pAb
Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-PTPN6-Y536 antibody .
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Background
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.
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References
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"