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  • Phospho-PTPN11-Y580 pAb

Phospho-PTPN11-Y580 pAb

Cat.#: 166447

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Product Information

  • Product Name
    Phospho-PTPN11-Y580 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-PTPN11-Y580
  • Tested applications
    IHC
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    PTPN11 antibody; BPTP3 antibody; CFC antibody; JMML antibody; METCDS antibody; NS1 antibody; PTP-1D antibody; PTP2C antibody; SH-PTP2 antibody; SH-PTP3 antibody; SHP2 antibody; tyrosine-protein phosphatase non-receptor type 11 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding Y580 of human PTPN11
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    IHC 1:50 - 1:100
  • Validations

    Immunohistochemistry - Phospho-PTPN11-Y580 pAb

    Immunohistochemistry - Phospho-PTPN11-Y580 pAb

    Immunohistochemistry of paraffin-embedded human breast carcinoma tissue, using Phospho-PTPN11-Y580 antibody .

  • Background
    Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"