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  • Phospho-PLCG1-S1248 pAb
  • Phospho-PLCG1-S1248 pAb

Phospho-PLCG1-S1248 pAb

Cat.#: 166533

Special Price 232.3 USD

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Product Information

  • Product Name
    Phospho-PLCG1-S1248 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-PLCG1-S1248
  • Tested applications
    WB, IHC
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    PLCG1 antibody; NCKAP3 antibody; PLC-II antibody; PLC1 antibody; PLC148 antibody; PLCgamma1 antibody; phospholipase C gamma 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic phosphorylated peptide around S1248 of human PLCG1 (NP_002651.2).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IHC 1:10 - 1:100
  • Validations

    Western blot - Phospho-PLCG1-S1248 pAb

    Western blot - Phospho-PLCG1-S1248 pAb

    Western blot analysis of extracts of Jurkat cells, using Phospho-PLCG1-S1248 antibody at dilution or PLCG1 antibody . Jurkat cells were treated by PMA/TPA (200 nM) at 37u2103 for 10 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit .Exposure time: 90s.

    Immunohistochemistry - Phospho-PLCG1-S1248 pAb

    Immunohistochemistry - Phospho-PLCG1-S1248 pAb

    Immunohistochemistry of paraffin-embedded human placenta using Phospho-PLCG1-S1248 antibody at dilution of 1:100 (40x lens).

  • Background
    Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"