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  • Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 pAb

Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 pAb

Cat.#: 166441

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Product Information

  • Product Name
    Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-PIK3R1/PIK3R2/PIK3R3-Y467
  • Tested applications
    WB
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding Y467 of human PIK3R1/2/3
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
  • Validations

    Western blot - Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 pAb

    Western blot - Phospho-PIK3R1/PIK3R2/PIK3R3-Y467 pAb

    Western blot analysis of extracts from 293 cells, using phospho-PIK3R1/2/3-Y467 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

  • Background
    Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"