Phospho-p53 (Ser46) Antibody

Phospho-p53 (Ser46) Antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Peptide affinitypurifiedRabbitPolyclonalAntibody(Pab)

WB

Human

P53 antibody; Cellular tumor antigen p53 antibody; Antigen NY-CO-13 antibody; Phosphoprotein p53 antibody; Tumor suppressor p53 antibody; TP53 antibody; P53 antibody

Rabbit IgG

Phospho-p53 (Ser46) Antibody detects endogenous levels of p53 only when phosphorylated at Serine 46

Polyclonal

Peptide affinity purified.Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.

WB: 1:500-1:2000

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.