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  • Phospho-p27 KIP 1-T187 pAb
  • Phospho-p27 KIP 1-T187 pAb

Phospho-p27 KIP 1-T187 pAb

Cat.#: 166403

Special Price 232.3 USD

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Product Information

  • Product Name
    Phospho-p27 KIP 1-T187 pAb
  • Documents
  • Description
    Polyclonal antibody to Phospho-p27 KIP 1-T187
  • Tested applications
    WB, IHC
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    CDKN1B antibody; CDKN4 antibody; KIP1 antibody; MEN1B antibody; MEN4 antibody; P27KIP1 antibody; cyclin-dependent kinase inhibitor 1B antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A phospho specific peptide corresponding to residues surrounding T187 of human p27 KIP 1
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
    IHC 1:50 - 1:100
  • Validations

    Western blot - Phospho-p27 KIP 1-T187 pAb

    Western blot - Phospho-p27 KIP 1-T187 pAb

    Western blot analysis of extracts from HeLa cells, using Phospho-p27 KIP 1-T187 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% BSA.

    Immunohistochemistry - Phospho-p27 KIP 1-T187 pAb

    Immunohistochemistry - Phospho-p27 KIP 1-T187 pAb

    Immunohistochemistry of paraffin-embedded human breast carcinoma tissue, using Phospho-p27 KIP 1-T187 antibody .

  • Background
    Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"