Polyclonal antibody to Phospho-MEF2A-T319
Human, Mouse, Rat
MEF2A antibody; ADCAD1 antibody; RSRFC4 antibody; RSRFC9 antibody; mef2 antibody; myocyte enhancer factor 2A antibody
Antigen: A phospho specific peptide corresponding to residues surrounding T319 of human MEF2A
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Store at -20℃. Avoid freeze / thaw cycles.
IF 1:100 - 1:200
Immunofluorescence - Phospho-MEF2A-T319 pAb
Immunofluorescence analysis of methanol-fixed HeLa cells using Phospho-MEF2A-T319 antibody .
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
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